1.e3 e6

White can play 2.Nf3.

White has many other options :

2.Qf3,

2.Qh5 g6 3.Nf3 (or 3.Qb5 c6 4. Nf3 Qh4 5.g3 f6) f6 (or 3...Qh4),

2.Bd3,

2.Nc3 Bb4,

2.Na3,

2.b4,

2.f3,

2.Nh3.